Item no.
NIST-8671
Unit
800 microliters
Shipment details
Dry ice shipment /not restricted
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Description
The NIST monoclonal antibody (NISTmAb) reference material (RM) is a recombinant humanized IgG1? expressed in murine suspension culture and has undergone biopharmaceutical industry standard upstream and downstream purification to remove process related impurities. It is an ~150 kDa homodimer of two light chain and two heavy chain subunits linked through both inter- and intra-chain disulfide bonds. The molecule has a high abundance of N-terminal pyroglutamination, C-terminal lysine clipping, and glycosylation of the heavy chains. The protein also has low abundance post-translational modifications including methionine oxidation, deamidation, and glycation. These and other product quality attributes were extensively characterized in the ACS Symposium Series for the initial batch of interim material, used as the primary standard (PS) herein.-
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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NIST provides over 1300 Standard Reference Materials® as well as articles and practice guides describing the development, analysis and use of SRMs.
NIST Standard Reference Materials are used by analytical laboratories in industry, academia and government in order to facilitate commerce and trade and to advance research and development. The SRMs are produced by the engineering laboratory, the material measurement laboratory, and the physical measurement laboratory at NIST. They are available for chemical composition, physical properties, and engineering materials.