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gamma-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem The gamma-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of gamma-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Item no.

SAF-565763-5MG

Unit

1 x 5 mg

Price on request

Description

A potent, cell-permeable inhibitor of gamma-secretase that blocks the formation of Abeta42 (IC50 = 1.8 µ,M). Treatment of HEK293 cells with gamma-secretase inhibitor VI results in an increase in beta-secretase-cleaved, APP fragments and secreted APPSalpha, but no change in secreted APPSbeta, indicating a specific inhibition of gamma-secretase activity., Cell permeable. Potently inhibits Abeta42 production (IC50 = 1.8 µ,M). Treatment of HEK293 cells with this inhibitor results in beta-Secretase-cleaved APP fragments and secreted APPalpha, but no change in secreted APPsbeta is observed indicating specific inhibition of gamma-secretase.

Structure formula

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