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NF-kappaB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem The NF-kappaB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-kappaB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Item no.

SAF-481411-5MG

Unit

1 x 5 mg

Shipment details

No Dangerous Good

Price on request

Description

A cell-permeable thiazoloamide compound that inhibits TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µ,M). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation., A cell-permeable inhibitor of TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µ,M). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.

Structure formula

Miscellaneous

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