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Beschreibung

A cell-permeable thiazoloamide compound that inhibits TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µ,M). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation., A cell-permeable inhibitor of TNF-alpha-stimulated NF-kappaB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µ,M). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-alpha-dependent cell invasion. Does not affect TNF-alpha-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.