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InSolution NF-kappaB Activation Inhibitor - Calbiochem The InSolution NF-kappaB Activation Inhibitor controls the biological activity of NF-kappaB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Item no.

SAF-481407-1MG

Unit

1 x 1 mg

Price on request

Description

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µ,M. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.

Structure formula

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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