Zurück zu Ihrem Suchergebnis

Beschreibung

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-kappaB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-alpha production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µ,M. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.