This Standard Reference Material (SRM®) is intended primarily for use in evaluating the accuracy of procedures for the determination of nicotine metabolites in human urine. It is also intended for use in validating working or secondary reference materials. NIST-3671 was prepared from normal human urine collected from three different populations: nonsmokers without environmental exposure to tobacco smoke, nonsmokers with exposure to secondhand smoke, and smokers who smoke at least one pack of cigarettes per day. A unit of NIST-3671 consists of three vials, each containing 10 mL of frozen human urine, one bottle each of three levels. /// Sample value(s) - please ask for current certificate.
Contents
Analyte
CAS Number
Concentration
Unit
Additional information
Method
Cotinine (total)
325,5 ± 17,4
ng/g
Level 2, certified value
Nicotine (free)
[54-11-5]
1436 ± 93
ng/g
Level 3, certified value
3-Hydroxycotinine (free)
4899 ± 108
ng/g
Level 3, certified value
Caffeine (free)
[58-08-2]
752,8 ± 83,9
ng/g
Level 1, reference value
Theobromine (free)
[83-67-0]
4260 ± 584
ng/g
Level 1, reference value
Nicotine (free)
[54-11-5]
113,5 ± 20,0
ng/g
Level 2, reference value
Nicotine glucuronide
77,9 ± 27,3
ng/g
Level 2, reference value
Nicotine (total)
[54-11-5]
143,1 ± 4,8
ng/g
Level 2, reference value
Cotinine glucuronide
194,2 ± 42,4
ng/g
Level 2, reference value
3-Hydroxycotinine (free)
493,9 ± 44.0
ng/g
Level 2, reference value
3-Hydroxycotinine (total)
677,6 ± 77
ng/g
Level 2, reference value
Cotinine-N-oxide (total)
46,3 ± 5,2
ng/g
Level 2, reference value
Nicotine-N-oxide (total)
68,4 ± 8,4
ng/g
Level 2, reference value
Caffeine (free)
[58-08-2]
833,3 ± 58,3
ng/g
Level 2, reference value
Ibuprofen (free)
[15687-27-1]
1131 ± 122
ng/g
Level 2, reference value
Theobromine (free)
[83-67-0]
5529 ± 704
ng/g
Level 2, reference value
Nicotine (total)
[54-11-5]
1274 ± 147
ng/g
Level 3, reference value
Cotinine (free)
1164 ± 294
ng/g
Level 3, reference value
Cotinine glucuronide
1629 ± 441
ng/g
Level 3, reference value
Cotinine (total)
2335 ± 190
ng/g
Level 3, reference value
3-Hydroxycotinine (total)
6424 ± 612
ng/g
Level 3, reference value
Cotinine-N-oxide (total)
485,4 ± 37,6
ng/g
Level 3, reference value
Nicotine-N-oxide (total)
627,0 ± 44,6
ng/g
Level 3, reference value
Caffeine (free)
[58-08-2]
1086 ± 380
ng/g
Level 3, reference value
Ibuprofen (free)
[15687-27-1]
4469 ± 241
ng/g
Level 3, reference value
Theobromine (free)
[83-67-0]
3311 ± 341
ng/g
Level 3, reference value
Nicotine (free)
[54-11-5]
13
ng/g
Level 1, informational value
Cotinine (free)
0,4
ng/g
Level 1, informational value
Cotinine (total)
0,6
ng/g
Level 1, informational value
3-Hydroxycotinine (free)
1,2
ng/g
Level 1, informational value
3-Hydroxycotinine (total)
0,6
ng/g
Level 1, informational value
Cotinine (free)
133
ng/g
Level 2, informational value
3-Hydroxycotinine glucuronide
160
ng/g
Level 2, informational value
3-Hydroxycotinine glucuronide
2244
ng/g
Level 3, informational value
Miscellaneous
Certificate of Analysis (specimen)
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