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Description

This Standard Reference Material (SRM) is intended for use in the identification and quantification of oxidatively damaged DNA base components for analysis by isotope-dilution techniques using either gas chromatography/mass spectrometry (GC/MS), or liquid chromatography/mass spectrometry (LC/MS) [2]. A unit of NIST-2396 is a set of 10 components, which includes eight oxidatively-modified, stable isotope-labeled DNA bases (Components 1 through 8), one stable isotope-labeled normal DNA nucleoside (Component 9), and one oxidatively-modified, stable isotope-labeled nucleoside (Component 10). Each vial of NIST-2396 contains 0.2 mL of the designated component described in further detail below: /// Sample value(s) - please ask for current certificate.

Contents

Analyte	Concentration	Unit	Additional information
8-OH-dGuo-15N5	0,945 ± 0,049		ID 10 (Certified optical density)
4,6-Diamino-5-formamidopyrimidine- (formyl-13C-4,6-diamino-15N2)	0,23	mmol/L	ID 1
2,6-Diamino-4-hydroxyformamidopyrimidine- (formyl-13C-5-amido-15N-6-amino-15N)	0,17	mmol/L	ID 2
8-Hydroxyadenine-8-13C-9-15N-(6-amino-15N)	0,15	mmol/L	ID 3
5-Hydroxycytosine-2-13C-1,3-15N2	0,23	mmol/L	ID 4
5-Hydroxyuracil-2,4,5,6-13C4-1,3-15N2	0,14	mmol/L	ID 5
5-(Hydroxymethyl)uracil-4,5-13C2-alpha,alpha-2H	0,1	mmol/L	ID 6
cis-Thymine glycol-alpha,alpha,alpha,6-2H4	0,1	mmol/L	ID 7
5-Hydroxy-5-methylhydantoin-2-13C-1,3-15N2	0,1	mmol/L	ID 8
2?-Deoxyguanosine-15N5	0,13	mmol/L	ID 9
7,8-Dihydro-8-oxo-2'-deoxyguanosine15N5 or 8-hydroxy-2'-deoxyguanosine-15 N5 Abbreviation: 8-OH-dGuo-15N5	0,093	mmol/L	ID 10

Analyte

CAS Number

Concentration

Unit

Additional information

Method

8-OH-dGuo-15N5

0,945 ± 0,049

ID 10 (Certified optical density)

4,6-Diamino-5-formamidopyrimidine- (formyl-13C-4,6-diamino-15N2)

0,23

mmol/L

ID 1

2,6-Diamino-4-hydroxyformamidopyrimidine- (formyl-13C-5-amido-15N-6-amino-15N)

0,17

mmol/L

ID 2

8-Hydroxyadenine-8-13C-9-15N-(6-amino-15N)

0,15

mmol/L

ID 3

5-Hydroxycytosine-2-13C-1,3-15N2

0,23

mmol/L

ID 4

5-Hydroxyuracil-2,4,5,6-13C4-1,3-15N2

0,14

mmol/L

ID 5

5-(Hydroxymethyl)uracil-4,5-13C2-alpha,alpha-2H

0,1

mmol/L

ID 6

cis-Thymine glycol-alpha,alpha,alpha,6-2H4

0,1

mmol/L

ID 7

5-Hydroxy-5-methylhydantoin-2-13C-1,3-15N2

0,1

mmol/L

ID 8

2?-Deoxyguanosine-15N5

0,13

mmol/L

ID 9

7,8-Dihydro-8-oxo-2'-deoxyguanosine15N5 or 8-hydroxy-2'-deoxyguanosine-15 N5 Abbreviation: 8-OH-dGuo-15N5

0,093

mmol/L

ID 10

Miscellaneous

Certificate of Analysis (specimen)

Reference Material CoA specimen: for the current lot, please contact your customer service representative at info@labmix24.com

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Product data sheet

View all available product details e.g. description, analytes/parameters, CAS Number, concentrations/values, sales unit/product format, method, source, transport information

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NIST provides over 1300 Standard Reference Materials® as well as articles and practice guides describing the development, analysis and use of SRMs.

NIST Standard Reference Materials are used by analytical laboratories in industry, academia and government in order to facilitate commerce and trade and to advance research and development. The SRMs are produced by the engineering laboratory, the material measurement laboratory, and the physical measurement laboratory at NIST. They are available for chemical composition, physical properties, and engineering materials.

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Description

Contents

Miscellaneous

Certificate of Analysis (specimen)

Product data sheet