Item no.
TRC-S115000-50MG
CAS Number
[304909-07-7]
Unit
50 mg
Shipment details
No Dangerous Good
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Description
Category: Inhibitors /// Appearance: Off-White to Pale Yellow Solid /// Application Notes: A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). /// References: Chen, J.K., et al.: Proc. Natl. Acad. Sci. USA, 99, 14071 (2002), Frank-Kamenetsky, M., et al.: J. Biol. 1, 10 (2002)
Structure formula
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