Item no.
TRC-P294480-5MG
CAS Number
[718630-59-2]
Unit
5 mg
Shipment details
No Dangerous Good
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Description
Category: Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators /// Appearance: Off-White to Pale Yellow Solid /// Application Notes: PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors. /// References: Alzani, R. et al.: Exp. Hematol., 38, 259 (2010)| Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010)| Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010)|
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