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Description

Category: Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators /// Appearance: Pale Yellow Solid /// Application Notes: A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2). /// References: Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007)| Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008)| Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008)| Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008)|