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Description
Appearance: Clear Colorless Oil to Off-White Waxy Solid /// Application Notes: Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer's disease and possibly vascular dementia (multi-infarct dementia). Memantine's method of action involves an uncompetitive, low-affinity, open-channel blocker, it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission. /// References: Lipton, S., Curr Alzheimer Res., 2, 155 (2005)
Structure formula

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Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.