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Description

Category: Chiral Reagents, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Colorless to Pale Yellow Oil /// Application Notes: A labelled synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. /// References: Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007)| Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008)| Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997)| Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995)|

Structure formula

Iloprost-d4 (Major)

Contents

Miscellaneous

Certificate of Analysis (specimen)

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Product data sheet

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TRC | Toronto Research Chemicals

Quality analytical standards and reference materials for food and environmental analysis, research

Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.