Item no.
TRC-I267300-10MG
CAS Number
[78919-13-8]
Unit
10 mg
Shipment details
Dry ice shipment
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Description
Category: Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Colourless Oil to Off-White Stick Solid /// Application Notes: A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. /// References: Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007)| Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008)| Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997)| Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995)|
Structure formula
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