Item no.
TRC-G303503-1MG
Unit
1 mg
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Description
Application Note: Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 ?M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 ?M in parasite development and [3H]-hypoxanthine uptake assays respectively).
Structure formula
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