Item no.
TRC-F763805-2.5MG
CAS Number
[1286739-19-2]
Unit
2,5 mg
Molecular formula
C29H28ClN7OS
Molecular weight
558,1
Shipment details
No Dangerous Good
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Description
Application Notes: p21-activated kinases (Paks) are serine/threonine protein kinases involved in cellular signaling pathways. PAK1 is an effector of Rho GTPase. PAKs are oncogenic kinases, which have been implicated as potential therapeutic targets. FRAX 597 is a PAK1 inhibitor that can reduce pancreatic cancer growth when used with Gemcitabine (G305000), an antineoplastic agent. /// References: Radu, M., et al.: Nat Rev Cancer. 14, 13 (2014), Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993)
Structure formula
Contents
Miscellaneous
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Product data sheet
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