Item no.
TRC-C992278-25MG
CAS Number
n/a
Unit
25 mg
Shipment details
De Minimis
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Description
Application Note: 4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor.
Structure formula
piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2h)-one.png)
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