Item no.
TRC-C051500-50MG
CAS Number
[1140909-48-3]
Unit
50 mg
Shipment details
No Dangerous Good
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Description
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators /// Appearance: Off-White Solid /// Application Notes: Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. /// References: Camp, R., et al.: Cancer, 86, 2259
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