Item no.
TRC-B592490-10MG
CAS Number
[674289-55-5]
Unit
10 mg
Molecular formula
C18H16N2O2
Molecular weight
292,33
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Description
Category: Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Bright Yellow Solid /// Application Notes: Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. /// References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)
Structure formula
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Contents
Miscellaneous
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