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Appearance: Light Yellow Solid /// Application Notes: 1-Bis(4-fluorophenyl)methyl Piperzaine-d8 is a labelled analogue of 1-Bis(4-fluorophenyl)methyl Piperzaine (B434875), which is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200. It is also an intermediate in synthesizing Flunarizine-d8 Dihydrochloride (F455202), which is a calcium channel blocker, fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). /// References: Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014)| Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014)| Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975)| Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979)| Nihard, P., et al.: Angiology, 33, 37 (1982)| Holmes, B., et al.: Drugs, 27, 6 (1984)|