Item no.
TRC-A621350-10MG
CAS Number
[545380-34-5]
Unit
10 mg
Shipment details
No Dangerous Good
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Description
Category: Amines, Aromatics, Heterocycles, Inhibitors /// Appearance: Off-White to Brownish-Yellow Solid /// Application Notes: QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-alpha production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways. /// References: Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)
Structure formula
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Contents
Miscellaneous
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