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Description

Appearance: White to Off-White Solid /// Application Notes: (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases. /// References: Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015| Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015

Structure formula

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

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