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Description

Application Notes: (3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester is an impurity of Intedanib (I666650), an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. /// References: Sun, L., et al.: J. Med. Chem., 41, 2588 (1998)| Xie, H., et al.: J. Med. Chem., 50, 4898 (2007)| Hilberg, F., et al.: Cancer Res., 68, 4774 (2008)| Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Structure formula

Contents

Analyte

CAS Number

Concentration

Unit

Additional information

Method

(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester

[1168152-06-4]

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Quality analytical standards and reference materials for food and environmental analysis, research

Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.