Item no.
TRC-A142805-25MG
Unit
25 mg
Molecular formula
C22H33NO5
Molecular weight
391,5
Shipment details
to be checked
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Description
Application Note: 2-Acetamido-2-(methoxycarbonyl)-4-(4-octylphenyl)butanoic acid is related to Fingolimod (F805000) which is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Structure formula
-4-(4-octylphenyl)butanoic%20acid.png)
Contents
Miscellaneous
Certificate of Analysis (specimen)
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