Item no.
TRC-A105002-10MG
CAS Number
[1217731-56-0]
Unit
10 mg
Molecular formula
C14H14D4N6O
Molecular weight
290,36
Shipment details
No Dangerous Good /not restricted
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Description
Category: Isotope Labelled Compounds, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White to Light Beige Solid /// Application Notes: Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Structure formula
Contents
Miscellaneous
Certificate of Analysis (specimen)
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