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Description

Recognizes the endogenous forms of PGC-1alpha, which includes the ~113 kDa PGC-1alpha protein and the ~38 kDa splice variant, in brown adipose tissue, liver, and kidney., PGC-1alpha is a co-activator of PPARalpha, PPARgamma, and other transcription factors and regulates the transcriptonal program of adaptive thermogenesis in brown adipose tissue, hepatic/renal gluconeogenesis, and muscle fiber type switching. The full-length protein is 113 kDa and is induced in brown adipose tissue by cold exposure, in liver and kidney by fasting, and in skeletal muscle by exercise. Alternative splicing of the full-length gene produces a 270 aa N-terminal splice variant that migrates at ~38 kDa and is induced by the same physiological signals that induce expression of the full-length protein. The N-terminal PGC-1alpha splice variant is also subject to post translational modifications that alter its migration and apparent molecular weight., This Anti-PGC-1alpha Mouse mAb (4C1.3) is validated for use in Immunoblotting, Immunocytochemistry, Immunoprecipitation, Paraffin Sections for the detection of PGC-1alpha., Protein G purified mouse monclonal antibody. Recognizes the endogenous forms of PGC-1alpha, which includes the ~113 kDa PGC-1alpha protein and the ~38 kDa splice variant.