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Description

Transmembrane receptor CD16-2 (UniProt: Q8R477, also known as CD16-2, Fcgr4, FcgRIV, Fc gammaRIV, FcgammaRIV, Fcgr3a, CD16-2, Transmembrane receptor CD16-2) is encoded by the Fcgr4 (also known as Fcgr3a, Fcrl3) gene (Gene ID: 245256) in murine species. Murine species express three classes of activating IgG Fc receptors, the high affinity receptor FcgRI, the low affinity receptor FcgRIII, and the FcgRIV or CD16-2. CD16-2, a novel mouse receptor that displays significant homology to CD16/FcgRIII. It is a receptor for soluble IgG2a and 2b complexes, but not necessarily for cellular bound IgG2a. CD16-2 is expressed in peripheral blood leukocytes and in spleen, thymus, colon, and intestine. Similar to other activating receptors, CD16-2 possesses a charged residue within its transmembrane domain that is necessary for association with an ITAM (immunoreceptor tyrosine-based activation motif) bearing accessory protein. Both CD16-2 (FcgRIV) and FcgRIII are considered to be essential for mediating type II and type III autoimmune responses via FcRc-LAT-dependent generation of C5a. However, FcgRIII-deficient mice display compensatory enhanced CD16-2 expression that offers protection from lung inflammation and exhibit reduced sensitivity to IgG2a/b-mediated hemolytic anemia. Ref.: Syed, S.N., et al (2009). Eur. J. Immunol. 39(12): 3343-3356, Mechetina, L.V., et al. (2002). Immunogenetics 54(7): 463-468.