Back to your search result

Description

Sodium bicarbonate transporter-like protein 11 (UniProt A2AJN7, also known as Bicarbonate transporter-related protein 1, NaBC1, Sodium borate cotransporter 1, Solute carrier family 4 member 11) is encoded by the Slc4a11 (also known as BTR1) gene (Gene ID 269356) in murine species. Bicarbonate (HCO3-) transporters are the principal regulators of pH in cells and play a vital role in acid-base movement in various tissues. There exist four types of HCO3- transporters, namely Cl-/-HCO3- exchangers, Na+/HCO3- cotransporters (NBCs), a K+/HCO3- cotransporter, and a Na+-driven Cl-/-HCO3- exchanger. SLC4A11 is a ubiquitously expressed 14-transmembrane protein existing as dimers within the plasma membrane. Originally classified as bicarbonate transporter, later stiudy conducted with cultured primary bovine corneal endothelial cells (BCECs) indicated that SLC4A11 mediates Na+-coupled hydroxide (OH-) transport, but not borate (B(OH)4-) or bicarbonate (HCO3-) transport in corneal endothelium. SLC4A11 gene mutations in human are linked to endothelial dystrophies, including CDPD (Corneal dystrophy and perceptive deafness), CHED2 (Corneal dystrophy, endothelial 2, autosomal recessive), and FECD4 (Corneal dystrophy, Fuchs endothelial, 4).