Item no.
SAF-566321-1MG
Unit
1 x 1 mg
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Description
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µ,M) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µ,M and 38 µ,M, respectively).
Structure formula
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