Item no.
SAF-5081480001
CAS Number
[82752-99-6]
Unit
EA
Molecular formula
C25H32ClN5O2 · HCl
Molecular weight
506.47
Shipment details
No Dangerous Good /not restricted
A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
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