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Description

Recombinant, human, interleukin-6 expressed in E. coli. Interleukin-6 is a protein produced by a number of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity. Stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B-cells, T-cells, and hepatocytes. Stimulates growth and inhibits constitutive protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Human sequence IL-6 is active on murine cells. 1 µ,g is equivalent to 7.0 x 103 WHO units., Recombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.