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Description

Fibroblast-specific protein-1 (FSP1)/S100A4 is a cytoplasmic calcium-binding protein belonging to the S100 superfamily of which at least 21 members have been identified so far. Researchers believe that FSP1/S1004A is highly expressed in fibroblasts (Iwano et al., 2001, Strutz et al., 1995), in epithelial and endothelial cells undergoing epithelial-mesenchymal transition (EMT) (Iwano et al., 2002, Zeisberg and Neilson, 2009), and epithelial cancer cells that complete a transition to a metastatic phenotype (Xue et al., 2003).