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Description

A cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells., A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1, ID50 = 34 nM for calpain-2, ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of beta-amyloid precursor protein to beta-amyloid (Abeta). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.