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Description

Unlike other class I HDAC enzymes, HDAC3 is found in co-repressor complexes with the SMRT/N-CoR proteins. HDAC3 contains a unique domain structure which includes both nuclear localization and nuclear export sequences. HDAC3 has been implicated in cancer, as HDAC inhibitors produce anti-proliferative effects in various cancer cells. HDAC3 may also play a role in heart disease, which may involve deacetylation of MEF2., Human recombinant HDAC3 (His-tag) produced in insect cells