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Category: Apoptosis, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders. /// References: De Azevedo, W.F. et al.: Eur. J. Biochem., 43, 518 (1997)| Planchais, S. et al.: Plant J., 12, 191 (1997)| Mgbonyebi O.P. et al.: Anticancer Res., 18, 751 (1998)| MacCallum, D.E. et al.: Cancer Res., 65, 5399 (2005)|