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Description

Category: Aromatics, Chiral Reagents, Heterocycles, Mutagenesis Research Chemicals, Nicotine Derivatives, Nitric Oxide Reagents /// Appearance: Light Yellow to Light Orange Low Melting Solid /// Application Notes: Nicotine-1'-N-oxide is a derivative of Nicotine (N412420) found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1'-N-oxide has also been identified as metabolites of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1'-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans. /// References: Phillipson, J.D., et al.: Phytochemistry, 14, 2683 (1975)| Sindelar, R.D., et al.: Appl. Environ. Microbiol., 38, 836 (1979)