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Description

Category: Aromatics, Chiral Reagents, Heterocycles, Mutagenesis Research Chemicals, Nicotine Derivatives, Nitric Oxide Reagents, /// Appearance: White to Pale Orange Solid /// Application Notes: Nicotine-1'-N-oxide is a derivative of Nicotine (N412420) found in the leaves, stems, and roots of N. tabacum, N. affinis and N. sylvestris. Nicotine-1'-N-oxide has also been identified as a metabolite of nicotine in animals and in man. The metabolism of nicotine in man proceeds by alternative routes of oxidation of nitrogen to form nicotine-1'-N-oxide (both diastereomers) or cotinine. The ratio of these two products has been suggested as an indicator of bladder cancer in humans. /// References: Phillipson, J.D., et al.: Phytochemistry, 14, 2683 (1975)| Sindelar, R.D., et al.: Appl. Environ. Microbiol., 38, 836 (1979), XXX