Item no.
TRC-M262819-0.5MG
Unit
0,5 mg
Molecular formula
C11H8D2N2O
Molecular weight
188,22
Shipment details
No Dangerous Good
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Description
Appearance: Light Brown Solid /// Application Notes: 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone, mediates photoperiodicity in mammals, inhibits cerebellar nitric oxide synthetase, peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action. /// References: Barchas, et al.: Nature, 214, 919 (1967)| Glass, J.D., et al.: Science, 214, 821 (1981)
Structure formula
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