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Description
Category: Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals, Steroids, /// Appearance: Pale Yellow to Light Yellow Solid /// Application Notes: Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.KAAD-Cyclopamine compound is unstable in solution. /// References: Taipale, J., et al.: Nature, 406, 1005 (2000)| Perron, M., et al.: Development, 130, 1565 (2003)|
Structure formula

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Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.