Item no.
TRC-H288505-250MG
Unit
250 mg
Shipment details
De Minimis
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Description
Application Note: 2-(2-Heptyn-1-ylthio)phenol is an intermediate in the synthesis of 2-(2-Heptynylthio)phenol Acetate (H288500), which is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and COX-2, with IC50 values of 17 and 0.8uM for human recombinant COX-1 and COX-2 respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1.
Structure formula
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Contents
Miscellaneous
Certificate of Analysis (specimen)
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Product data sheet
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