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Description

Category: Agonist, Nucleotides, Bases and Related Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Off-White Solid /// Application Notes: A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II. /// References: Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010)| Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010)| Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008)| Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011)|