Item no.
TRC-D435305-50MG
CAS Number
[380843-81-2]
Unit
50 mg
Shipment details
No Dangerous Good
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Description
Application Notes: Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors. /// References: Lai, A. C., et al., Angew. Chem. Int. Ed. 55, 807 (2016)| Sakkiah, S., et al., J. Enzyme Inhib. Med. Chem. 29, 69 (2014)
Structure formula
![4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile](https://labmix24.com/gfx/formula/4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile.png)
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