(6S,11R,16S,21S)-21,6-Dibenzyl 22-tert-butyl 11,16-bis((2-(benzyloxy)-2-oxoethyl)carbamoyl)-2,2-dimethyl-4,9,18-trioxo-3-oxa-13,14-dithia-5,10,17-triazadocosane-6,21,22-tricarboxylate-d10 - TRC-D417417-2.5MG

Description

Application Notes: (6S,11R,16S,21S)-21,6-Dibenzyl 22-tert-butyl 11,16-bis((2-(benzyloxy)-2-oxoethyl)carbamoyl)-2,2-dimethyl-4,9,18-trioxo-3-oxa-13,14-dithia-5,10,17-triazadocosane-6,21,22-tricarboxylate-d10 is an intermediate of Glutathione Ammonium Salt-d5 which is the isotope labelled analog of Glutathione. Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. /// References: Misko, T., et al.: J. Biol. chem., 273, 15646 (1998), Nakamura, K., et al.: J. Biol. Chem., 276, 34402 (2001)

Structure formula

(6S,11R,16S,21S)-21,6-Dibenzyl 22-tert-butyl 11,16-bis((2-(benzyloxy)-2-oxoethyl)carbamoyl)-2,2-dimethyl-4,9,18-trioxo-3-oxa-13,14-dithia-5,10,17-triazadocosane-6,21,22-tricarboxylate-d10

Contents

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Method

(6S,11R,16S,21S)-21,6-Dibenzyl 22-tert-butyl 11,16-bis((2-(benzyloxy)-2-oxoethyl)carbamoyl)-2,2-dimethyl-4,9,18-trioxo-3-oxa-13,14-dithia-5,10,17-triazadocosane-6,21,22-tricarboxylate-d10

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