Item no.
TRC-C781800-5MG
CAS Number
[1797008-57-1]
Unit
5 mg
Molecular formula
C28H30F3N5O4
Molecular weight
557,56
Shipment details
No Dangerous Good
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Description
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Tyrosine Kinase Inhibitors /// Appearance: White to Off-White Solid /// Application Notes: Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. Crenolanib (CP-868569) inhibits the activity of PDGFRalpha D842V kinase and prevented the phosphorylation of wild type PDGFRalpha. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation. /// References: Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010)| Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009)|
Structure formula
Contents
Miscellaneous
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