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Description

Appearance: Pale Yellow Solid /// Application Notes: 4-[4-(3-Chloropropyl)-1-piperazinyl]-2-(1,1-dimethylethyl)-6-(trifluoromethyl)pyrimidine is an intermediate in the synthesis of ABT 925 Fumerate (A112600) is a dopamine D3 receptor antagonist that is used in the treatment of acute schizophrenia. 4-[4-(3-Chloropropyl)-1-piperazinyl]-2-(1,1-dimethylethyl)-6-(trifluoromethyl)pyrimidine is also used in the preparation of of other dopamine D3 receptor modulators such as 1-(4-pyrimidinyl)piperazines and pyrimidin-2-ones, that are used to treat central nervous system disorders. /// References: Redden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011)| Abbott, G.m.b.h. & Co.: Ger. Offen. DE 10311065 A1, 20040923 (2004)| Geneste, H., et al.: PCT Int. Appl., WO 2005118558 A2 20051215 (2005)

Structure formula

4-[4-(3-Chloropropyl)-1-piperazinyl]-2-(1,1-dimethylethyl)-6-(trifluoromethyl)pyrimidine

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TRC | Toronto Research Chemicals

Quality analytical standards and reference materials for food and environmental analysis, research

Founded in 1982, Toronto Research Chemicals is specialized in the development and production of reference materials used in research as well as food safety testing and environmental analysis. The range of more than 350,000 products includes reference standards for pesticides and metabolites, impurities, natural compounds and complex organic small molecules not otherwise commercially available.