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Description

Appearance: White to Off-White Solid /// Application Notes: Chenodeoxycholic Acid-d7 is a labelled analogue of Chenodeoxycholic Acid (C291900), which is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. In addition, Chenodeoxycholic Acid-d7 is an intermediate in synthesizing Glycochenodeoxycholic Acid-d7 Sodium Salt (G641257), which is a labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. /// References: Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972)| Iser, J.H., et al.: Drugs, 21, 90 (1981)| Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986)| Ollila, F., et al.: Langmuir, 17, 7107 (2001)| Uekama, K., et al.: Chem. Pharm. Bull., 52, 900