N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide - TRC-B812310-250MG

Description

Application Note: N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide is an intermediate in the synthesis of N-Hydroxy-N-(4-butyl-2-methylphenyl)formamidine (H831225), which is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYPs: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).

Structure formula

Contents

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CAS Number

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Additional information

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N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide

[398144-05-3]

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