Item no.
TRC-B691475-25MG
CAS Number
[159351-68-5]
Unit
25 mg
Molecular formula
C59H97NO14Si
Molecular weight
1072,49
Shipment details
No Dangerous Good
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Description
Appearance: White to Off-White Solid /// Application Notes: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400), an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. /// References: Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001)| Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001)| Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)| Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012
Structure formula
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