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Category: Amino Acids and Derivatives, Peptides, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Off-White Solid /// Application Notes: Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle. /// References: Ward, J.B. et al.: Biochem. J., 141, 227 (1974)| Anastasi, A. et al.: Biochem. J., 290, 601 (1993)| Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985)| Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967)|