Item no.
TRC-A771726-10MG
CAS Number
[163451-81-8]
Unit
10 mg
Molecular formula
C12H9F3N2O2
Molecular weight
270,21
Shipment details
De Minimis UN2811 (6.1) III E1
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Description
Category: Metabolites and Impurities, Tyrosine Kinase Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme's teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). /// References: Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)
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Structure formula
Contents
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